MTHFR gets a lot of attention, but it is not the whole story. Other genes like COMT and HNMT, along with environmental stressors, can explain why symptoms linger even when folate is supported. Here’s why looking at the full picture matters.

You’re taking the right steps but still don’t feel like yourself. Fatigue, anxiety, and brain fog could be tied to how your body processes key nutrients and hormones. Here’s how methylation plays a role, and why I often recommend genetic testing as a helpful next step.